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Increased ratio of dietary carbohydrate to protein shifts the focus of metabolic signaling from skel

22-Jun-2012

Suzanne Devkota and Donald K Layman

Nutrition & Metabolism 2011, 8:13 doi:10.1186/1743-7075-8-13

Published: 4 March 2011

Abstract (provisional)

Background

The Dietary Reference Intakes (DRI) established acceptable macronutrient distribution ranges (AMDR) for carbohydrates and protein, however little is known about differences in glycemic regulations and metabolic signaling across this range. This study examined metabolic outcomes associated with intake of two diets differing in carbohydrate:protein ratios representing the upper and lower ends of the AMDR.

Methods

Adult, male rats were fed either a high carbohydrate (CHO) diet (60% of energy from carbohydrates, 12% protein, 28% fat; n=30) or a high protein (PRO) diet (35% carbohydrate, 35% protein, 30% fat; n=30). Rats were meal-fed 3x/d the respective diets for 10 d and then terminated after overnight food deprivation or 30, 60, 90, 120 min post-prandial (PP). Plasma was collected at each of these points to provide a time course for glucose, insulin and C-peptide. Skeletal muscle and adipose tissues were collected at 0, 30 and 90 min for measurements of basal, early and delayed activation of Akt, p70S6K and Erk 1/2. Data were analyzed by two-way ANOVA.

Results

The CHO group produced a consistently elevated response in plasma glucose, insulin and C-peptide following the meal through the 120 min time course. In addition, Akt and Erk 1/2 activation in adipose was much higher than in skeletal muscle. Conversely, the PRO group PP glucose response was minimal and insulin maintained a response similar to a biphasic pattern. Tissue responses for the PRO group were greater for Akt and p70S6K signaling in skeletal muscle compared with adipose.

Conclusion

Taken together these data suggest that altering CHO:PRO ratios within the AMDR

Full paper http://www.nutritionandmetabolism.com/content/pdf/1743-7075-8-13.pdf



Products

CoolStance

CoolStance copra is a unique horse feed because it has low Non Structural Carbohydrate (NSC), and yet has a high digestible energy content.
Learn More

 

PowerStance

PowerStance is a unique powdered coconut oil supplement.  PowerStance delivers the secret ingredient from CoolStance as a powder.
Learn More